You thought that cartoon humans could just stand by for years and watch animals beat up on each other and not be affected by all that brutality? You thought wrong. Granny (Tweety and Sylvester) and Mammy Two-Shoes (Tom and Jerry) have witnessed so much senseless violence that they've become senselessly violent themselves, and since they're bored with just hitting a cat with an umbrella and/or rolling pin, they decide to fight with each other. Who wins this battle of cartoon ladies?
The advantages for Mammy: she's probably younger (for obvious reasons it's hard to tell), generally angrier, and she appears to be quite a bit smarter than the dotty Granny. But Granny has displayed more physical prowess, like hiding in a birdcage or surviving an explosion by a nitro-filled cat.