Sort of like a "grudge match I'd like to see," except instead of imagining a fight, we ask what would happen if a TV show were done with a few minor tweaks:
Scenario: The show Buffy the Vampire Slayer has the same setup we're familiar with: an ordinary girl named Buffy discovers that she is the Chosen One with the power to fight vampires and other monsters. She protects the town from evil under the guidance of her British Watcher. The only difference is that Buffy is Buffy Patterson from Family Affair, and her Watcher is Mr. French, who was placed with Uncle Bill by the Watcher's Council for the express purpose of guiding Buffy to her destiny.
Can Buffy protect New York from vampires? How will Jody, Uncle Bill and Cissy deal with being the new Scooby Gang? Speculation welcome.